Functional Heterogeneity of CD4+ Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC

Resident memory T cells (TRM) inhabit peripheral tissues and are critical for protection against localized infections. Recently, it has become evident that CD103+ TRM are not only important in combating secondary infections, but also for the elimination of tumor cells. In several solid cancers, intr...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Anna E. Oja, Berber Piet, David van der Zwan, Hans Blaauwgeers, Mark Mensink, Sander de Kivit, Jannie Borst, Martijn A. Nolte, René A. W. van Lier, Regina Stark, Pleun Hombrink
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-11-01
Subjects:	NSCLC TRM TILs cytokines exhaustion differentiation
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2018.02654/full