Homogeneous Space Construction and Projection for Single-Cell Expression Prediction Based on Deep Learning

Predicting cellular responses to perturbations is an unsolved problem in biology. Traditional approaches assume that different cell types respond similarly to perturbations. However, this assumption does not take into account the context of genome interactions in different cell types, which leads to...

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Bibliographic Details

Published in:	Bioengineering
Main Authors:	Chia-Hung Yeh, Ze-Guang Chen, Cheng-Yue Liou, Mei-Juan Chen
Format:	Article
Language:	English
Published:	MDPI AG 2023-08-01
Subjects:	cell perturbation response prediction disentangled representations cell response homogeneous space construction deep learning interpretability
Online Access:	https://www.mdpi.com/2306-5354/10/9/996