Personalized Vascularized Models of Breast Cancer Desmoplasia Reveal Biomechanical Determinants of Drug Delivery to the Tumor

Abstract Desmoplasia in breast cancer leads to heterogeneity in physical properties of the tissue, resulting in disparities in drug delivery and treatment efficacy among patients, thus contributing to high disease mortality. Personalized in vitro breast cancer models hold great promise for high‐thro...

وصف كامل

التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Advanced Science
المؤلفون الرئيسيون:	Giovanni S. Offeddu, Elena Cambria, Sarah E. Shelton, Kristina Haase, Zhengpeng Wan, Luca Possenti, Huu Tuan Nguyen, Mark R. Gillrie, Dean Hickman, Charles G. Knutson, Roger D. Kamm
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Wiley 2024-10-01
الموضوعات:	hyaluronic acid microphysiological systems permeability TGFβ mechanotherapy tumor vascularization vascular glycocalyx
الوصول للمادة أونلاين:	https://doi.org/10.1002/advs.202402757