PGC1α is required for the renoprotective effect of lncRNA Tug1 in vivo and links Tug1 with urea cycle metabolites

Summary: lncRNA taurine-upregulated gene 1 (Tug1) is a promising therapeutic target in the progression of diabetic nephropathy (DN), but the molecular basis of its protection remains poorly understood. Here, we generate a triple-mutant diabetic mouse model coupled with metabolomic profiling data to...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Li Li, Jianyin Long, Koki Mise, Daniel L. Galvan, Paul A. Overbeek, Lin Tan, Shwetha V. Kumar, Wai Kin Chan, Phillip L. Lorenzi, Benny H. Chang, Farhad R. Danesh
Format:	Article
Language:	English
Published:	Elsevier 2021-08-01
Subjects:	RNA lncRNA Tug1 PGC1α podocytes diabetic nephropathy
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124721009402