HM015k, a Novel Silybin Derivative, Multi-Targets Metastatic Ovarian Cancer Cells and Is Safe in Zebrafish Toxicity Studies

This study was designed to determine the in vitro mechanisms by which the novel silybin derivative, (E)-3-(3-(benzyloxy) phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one (HM015k or 15k), produces its anticancer efficacy in ovarian cancer cells. Compound 15k induced apoptosis in ovarian cancer cells in a t...

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發表在:	Frontiers in Pharmacology
Main Authors:	Haneen Amawi, Noor A. Hussein, Chandrabose Karthikeyan, Elangovan Manivannan, Alexander Wisner, Frederick E. Williams, Temesgen Samuel, Piyush Trivedi, Charles R. Ashby, Amit K. Tiwari
格式:	Article
語言:	英语
出版:	Frontiers Media S.A. 2017-08-01
主題:	ovarian cancer silybin silymarin metastasis apoptosis epithelial-mesenchymal transition
在線閱讀:	http://journal.frontiersin.org/article/10.3389/fphar.2017.00498/full