Epigenetic regulation by polycomb repressive complex 1 promotes cerebral cavernous malformations

Abstract Cerebral cavernous malformations (CCMs) are anomalies of the cerebral vasculature. Loss of the CCM proteins CCM1/KRIT1, CCM2, or CCM3/PDCD10 trigger a MAPK-Krüppel-like factor 2 (KLF2) signaling cascade, which induces a pathophysiological pattern of gene expression. The downstream target ge...

Full description

Bibliographic Details

Published in:	EMBO Molecular Medicine
Main Authors:	Van-Cuong Pham, Claudia Jasmin Rödel, Mariaelena Valentino, Matteo Malinverno, Alessio Paolini, Juliane Münch, Candice Pasquier, Favour C Onyeogaziri, Bojana Lazovic, Romuald Girard, Janne Koskimäki, Melina Hußmann, Benjamin Keith, Daniel Jachimowicz, Franziska Kohl, Astrid Hagelkruys, Josef M Penninger, Stefan Schulte-Merker, Issam A Awad, Ryan Hicks, Peetra U Magnusson, Eva Faurobert, Massimiliano Pagani, Salim Abdelilah-Seyfried
Format:	Article
Language:	English
Published:	Springer Nature 2024-10-01
Subjects:	CBX7 Cerebral Cavernous Malformation endoMT KLF2 WNT9
Online Access:	https://doi.org/10.1038/s44321-024-00152-9