Crosstalk between lactylation and RNA modifications in tumorigenesis: mechanisms and therapeutic implications

Abstract Complex crosstalk occurs between protein and nucleic acid modifications, with lactylation, an emerging post-translational modification (PTM), being implicated in tumor progression. However, the mechanisms mediating the crosstalk between lactylation and RNA modifications and their roles in d...

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Bibliographic Details

Published in:	Biomarker Research
Main Authors:	Shantong Liu, Qianquan Ma, Chong Zeng, Haoyu Li, Jun Su, Zhihao Song, Ruyu Yan, Zijin Zhao, Songhai Tian, Wei Huang
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Subjects:	Lactylation modification RNA modification Crosstalk Positive feedback loop Targeted therapy
Online Access:	https://doi.org/10.1186/s40364-025-00824-9