PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by influencing synaptic function in the primary motor cortex of rats

Proline-rich transmembrane protein 2 (PRRT2) was identified as the causative gene of paroxysmal kinesigenic choreoathetosis (PKC) as well as various other neurological diseases. However, the molecular mechanisms of how mutant PRRT2 leads to abnormal synaptic function and triggers PKC are still obscu...

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发表在:	Neurobiology of Disease
Main Authors:	Juan Mo, Bantong Wang, Xilin Zhu, Xiaopan Wu, Ying Liu
格式:	文件
语言:	英语
出版:	Elsevier 2019-01-01
主题:	PRRT2 Paroxysmal kinesigenic choreoathetosis M1 cortex SNARE complex Synaptic transmission
在线阅读:	http://www.sciencedirect.com/science/article/pii/S096999611830679X