Metformin suppresses epithelial sodium channel hyperactivation and its associated phenotypes in a mouse model of obstructive lung diseases

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the world, and has no radical treatment. Inhibition of amiloride-sensitive epithelial sodium ion channel (ENaC) has now been considered as a potential therapeutic target against COPD. One possible modulator of ENaC...

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Bibliographic Details

Published in:	Journal of Pharmacological Sciences
Main Authors:	Ryunosuke Nakashima, Hirofumi Nohara, Noriki Takahashi, Aoi Nasu, Megumi Hayashi, Tomoki Kishimoto, Shunsuke Kamei, Haruka Fujikawa, Kasumi Maruta, Taisei Kawakami, Yuka Eto, Keiko Ueno-Shuto, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto
Format:	Article
Language:	English
Published:	Elsevier 2022-06-01
Subjects:	Chronic obstructive pulmonary disease (COPD) Epithelial Na+ channel (ENaC) Metformin AMP-Activated protein kinase (AMPK)
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861322000226