Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer

Previous studies found patients with POLE exonuclease domain mutations (EDMs) in targeted exons were related to significant better outcomes in stage II-III colorectal cancer (CRC). The detailed mutational profile of the entire POLE exonuclease domain, tumor mutation burden (TMB) and immune cell infi...

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Bibliographic Details

Published in:	Journal for ImmunoTherapy of Cancer
Main Authors:	Dan Huang, Sanjun Cai, Long Zhang, Junjie Peng, Shaobo Mo, Xiaoji Ma, Yaqi Li, Ting Hou, Han Han-Zhang, Juanjuan Qian
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2020-10-01
Online Access:	https://jitc.bmj.com/content/8/2/e000881.full