Characterization of LY3324954 a long-acting glucagon-receptor agonist

Objective: Glucagon is a crucial regulator of glucose and lipid metabolism as well as whole-body energy balance. Thus, modulation of glucagon receptor (GCGR) activity in the context of single-molecule multi-receptor co-agonists has become an emerging therapeutic target against obesity and obesity-as...

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Bibliographic Details

Published in:	Molecular Metabolism
Main Authors:	William Roell, Tamer Coskun, Teayoun Kim, Libbey O’Farrell, Jennifer A. Martin, Shelly Nason, Jasmin Hernandez-Alamillo, Saidharshana Dhantu, Daniel J. Drucker, Kyle W. Sloop, James P. Steele, Jorge Alsina-Fernandez, Kirk M. Habegger
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Subjects:	Glucagon Insulin secretion Glucose homeostasis Diabetes Obesity
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877824002047