Immune checkpoint ligands expressed on mature high endothelial venules predict poor prognosis of NSCLC: have a relationship with CD8+ T lymphocytes infiltration

BackgroundAn insufficient number of intratumoral CD8+ T lymphocytes is a major barrier to antitumor immunity and immunotherapy. High endothelial venules (HEVs) are the major sites through which lymphocytes enter tumors; however, the molecular mechanism through which HEVs mediate CD8+ T lymphocyte in...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Jing Luo, Xiuhuan Shi, Yumeng Liu, Jian Wang, Hao Wang, Xuena Yang, Qian Sun, Zhenzhen Hui, Feng Wei, Xiubao Ren, Hua Zhao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Subjects:	lung cancer immune checkpoint ligands high endothelial venules lymphocytes infiltration tertiary lymphoid structures
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1302761/full