A structural and mechanistic model for BSEP dysfunction in PFIC2 cholestatic disease
Abstract BSEP (ABCB11) transports bile salts across the canalicular membrane of hepatocytes, where they are incorporated into bile. Biallelic mutations in BSEP can cause Progressive Familial Intrahepatic Cholestasis Type 2 (PFIC2), a rare pediatric disease characterized by hepatic bile acid accumula...
| Published in: | Communications Biology |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
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| Online Access: | https://doi.org/10.1038/s42003-025-07908-0 |