The Action Potential Clamp Technique as a Tool for Risk Stratification of Sinus Bradycardia Due to Loss-of-Function Mutations in HCN4: An In Silico Exploration Based on In Vitro and In Vivo Data

These days, in vitro functional analysis of gene variants is becoming increasingly important for risk stratification of cardiac ion channelopathies. So far, such risk stratification has been applied to <i>SCN5A</i>, <i>KCNQ1</i>, and <i>KCNH2</i> gene variants ass...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Arie O. Verkerk, Ronald Wilders
Format:	Article
Language:	English
Published:	MDPI AG 2023-09-01
Subjects:	sinoatrial node human pacemaker activity hyperpolarization-activated current <i>HCN4</i> channels cellular electrophysiology
Online Access:	https://www.mdpi.com/2227-9059/11/9/2447