Selective anti-tumor activity of glutathione-responsive abasic site trapping agent in anaplastic thyroid carcinoma

Abstract Anaplastic thyroid carcinoma (ATC) is a rare but highly aggressive thyroid cancer with poor prognosis. Killing cancer cells by inducing DNA damage or blockage of DNA repair is a promising strategy for chemotherapy. It is reported that aldehyde-reactive alkoxyamines can capture the AP sites,...

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Bibliographic Details

Published in:	BMC Cancer
Main Authors:	Jinyan Chai, Mengxue Su, Ruiguo Zhang, Ning Li, Yuanyuan Jia, Wei Zheng, Jian Tan, Qiang Jia, Huabing Sun, Zhaowei Meng
Format:	Article
Language:	English
Published:	BMC 2024-07-01
Subjects:	Anaplastic thyroid carcinoma Glutathione Abasic sites Apurinic/apyrimidinic endonuclease 1
Online Access:	https://doi.org/10.1186/s12885-024-12511-3