Insights into the diverse mechanisms and effects of variant CUL3-induced familial hyperkalemic hypertension

Abstract Familial hyperkalemic hypertension (FHHt), also known as Pseudohypoaldosteronism type II (PHAII) or Gordon syndrome is a rare Mendelian disease classically characterized by hyperkalemia, hyperchloremic metabolic acidosis, and high systolic blood pressure. The most severe form of the disease...

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Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Prashant Sharma, Harish E. Chatrathi
Format:	Article
Language:	English
Published:	BMC 2023-10-01
Subjects:	CUL3 Hyperkalemia Hypertension Post-translational modifications Substrate-adaptor binding
Online Access:	https://doi.org/10.1186/s12964-023-01269-z