The PKCι-β-arrestin2 axis disrupts SORLA retrograde trafficking, driving its degradation and amyloid pathology in Alzheimer’s disease

Abstract Background Variants of SORL1 have been associated with both late and early onset of Alzheimer’s disease (AD). SORL1 encodes the sorting-related receptor with A repeat (SORLA) protein, which belongs to the VPS10 receptor family. SORLA protects against AD pathogenesis through its sorting func...

Full description

Bibliographic Details

Published in:	Molecular Neurodegeneration
Main Authors:	Hasibur Rehman, Shun Yan, Shalini Saggu, Mae Aida, Fang Zhang, Yang Shu, Alexis Jones, Amy Trang, Emily Dew, Wenbo Zhi, Emily T. Claeboe, Anthony J. Baucum, Guangyu Wu, Kai Jiao, Qin Wang
Format:	Article
Language:	English
Published:	BMC 2025-06-01
Subjects:	SORLA PKCι/λ βarrestin2 Alzheimer’s disease Protein–protein interaction Trafficking
Online Access:	https://doi.org/10.1186/s13024-025-00865-6