The TPR domain of PgaA is a multifunctional scaffold that binds PNAG and modulates PgaB-dependent polymer processing.

The synthesis of exopolysaccharides as biofilm matrix components by pathogens is a crucial factor for chronic infections and antibiotic resistance. Many periplasmic proteins involved in polymer processing and secretion in Gram-negative synthase dependent exopolysaccharide biosynthetic systems have b...

Full description

Bibliographic Details

Published in:	PLoS Pathogens
Main Authors:	Roland Pfoh, Adithya S Subramanian, Jingjing Huang, Dustin J Little, Adam Forman, Benjamin R DiFrancesco, Negar Balouchestani-Asli, Elena N Kitova, John S Klassen, Régis Pomès, Mark Nitz, P Lynne Howell
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2022-08-01
Online Access:	https://doi.org/10.1371/journal.ppat.1010750