Constructing multilayer PPI networks based on homologous proteins and integrating multiple PageRank to identify essential proteins

Abstract Background Predicting and studying essential proteins not only helps to understand the fundamental requirements for cell survival and growth regulation mechanisms but also deepens our understanding of disease mechanisms and drives drug development. Existing methods for identifying essential...

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Bibliographic Details

Published in:	BMC Bioinformatics
Main Authors:	He Zhao, Huan Xu, Tao Wang, Guixia Liu
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	Essential proteins Homologous proteins Multilayer PPI networks Multiple PageRank
Online Access:	https://doi.org/10.1186/s12859-025-06093-5