Evaluation of Engineered CRISPR-Cas-Mediated Systems for Site-Specific RNA Editing

Summary: Site-directed RNA editing approaches offer great potential to correct genetic mutations in somatic cells while avoiding permanent off-target genomic edits. Nuclease-dead RNA-targeting CRISPR-Cas systems recruit functional effectors to RNA molecules in a programmable fashion. Here, we demons...

Full description

Bibliographic Details

Published in:	Cell Reports
Main Authors:	Ryan J. Marina, Kristopher W. Brannan, Kevin D. Dong, Brian A. Yee, Gene W. Yeo
Format:	Article
Language:	English
Published:	Elsevier 2020-11-01
Subjects:	RNA editing Cas9 Cas13 ADAR2 CRISPR transcriptome engineering
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124720313395