Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase

Abstract The dual functions of TMEM16F as Ca2+-activated ion channel and lipid scramblase raise intriguing questions regarding their molecular basis. Intrigued by the ability of the FDA-approved drug niclosamide to inhibit TMEM16F-dependent syncytia formation induced by SARS-CoV-2, we examined cryo-...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Shengjie Feng, Cristina Puchades, Juyeon Ko, Hao Wu, Yifei Chen, Eric E. Figueroa, Shuo Gu, Tina W. Han, Brandon Ho, Tong Cheng, Junrui Li, Brian Shoichet, Yuh Nung Jan, Yifan Cheng, Lily Yeh Jan
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-08-01
Online Access:	https://doi.org/10.1038/s41467-023-40410-x