Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue

<i>hERG</i> (<i>human Ether-à-go-go Related Gene</i>)-encoded potassium channels underlie the cardiac rapid delayed rectifier (I<sub>Kr</sub>) potassium current, which is a major target for antiarrhythmic agents and diverse non-cardiac drugs linked to the drug-ind...

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Bibliographic Details
Published in:Pharmaceuticals
Main Authors: Matthew V. Helliwell, Yihong Zhang, Aziza El Harchi, Christopher E. Dempsey, Jules C. Hancox
Format: Article
Language:English
Published: MDPI AG 2023-08-01
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Online Access:https://www.mdpi.com/1424-8247/16/9/1204