Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling

Recurrent joint bleeding in hemophilia patients frequently causes hemophilic arthropathy (HA). Drastic degradation of cartilage is a major characteristic of HA, but its pathological mechanisms has not yet been clarified. In HA cartilages, we found server matrix degradation and increased expression o...

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Bibliographic Details

Published in:	eLife
Main Authors:	Jiali Chen, Qinghe Zeng, Xu Wang, Rui Xu, Weidong Wang, Yuliang Huang, Qi Sun, Wenhua Yuan, Pinger Wang, Di Chen, Peijian Tong, Hongting Jin
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2024-05-01
Subjects:	hemophilic arthropathy DNA methylation tenascin XB cartilage degeneration chondrocyte apoptosis
Online Access:	https://elifesciences.org/articles/93087