Genomic analyses of germline and somatic variation in high-grade serous ovarian cancer

Abstract Background High-grade serous ovarian cancers (HGSCs) display a high degree of complex genetic alterations. In this study, we identified germline and somatic genetic alterations in HGSC and their association with relapse-free and overall survival. Using a targeted capture of 557 genes involv...

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Bibliographic Details

Published in:	Journal of Ovarian Research
Main Authors:	A. W. Adamson, Y. C. Ding, L. Steele, L. A. Leong, R. Morgan, M. T. Wakabayashi, E. S. Han, T. H. Dellinger, P. S. Lin, A. A. Hakim, S. Wilczynski, C. D. Warden, S. Tao, V. Bedell, M. C. Cristea, S. L. Neuhausen
Format:	Article
Language:	English
Published:	BMC 2023-07-01
Subjects:	High-grade serous ovarian cancer Homologous recombination repair Germline mutations Somatic mutations Somatic copy number alterations
Online Access:	https://doi.org/10.1186/s13048-023-01234-x