Loss of NSD2 causes dysregulation of synaptic genes and altered H3K36 dimethylation in mice

Background: Epigenetic disruptions have been implicated in neurodevelopmental disorders. NSD2 is associated with developmental delay/intellectual disability; however, its role in brain development and function remains unclear.Methods: We performed transcriptomic and epigenetic analyses using Nsd2 kn...

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Bibliographic Details

Published in:	Frontiers in Genetics
Main Authors:	Shiori Kinoshita, Kazuaki Kojima, Eriko Ohnishi, Yuka Takayama, Hiroki Kikuchi, Shuji Takada, Kazuhiko Nakabayashi, Tomoko Kawai, Kenichiro Hata
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Subjects:	NSD2 neurodevelopmental disorder RNA sequencing ChIP sequencing H3K36me2
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2024.1308234/full