A cryptic K48 ubiquitin chain binding site on UCH37 is required for its role in proteasomal degradation

Degradation by the 26 S proteasome is an intricately regulated process fine tuned by the precise nature of ubiquitin modifications attached to a protein substrate. By debranching ubiquitin chains composed of K48 linkages, the proteasome-associated ubiquitin C-terminal hydrolase UCHL5/UCH37 serves as...

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書誌詳細

出版年:	eLife
主要な著者:	Jiale Du, Sandor Babik, Yanfeng Li, Kirandeep K Deol, Stephen J Eyles, Jasna Fejzo, Marco Tonelli, Eric Strieter
フォーマット:	論文
言語:	英語
出版事項:	eLife Sciences Publications Ltd 2022-04-01
主題:	Ubiquitin deubiquitinase Proteasome
オンライン･アクセス:	https://elifesciences.org/articles/76100