Synthesis, Molecular Simulation, DFT, and Kinetic Study of Imidazotriazole-Based Thiazolidinone as Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase Enzymes

<b>Background:</b> Alzheimer’s disease is a complex and multifactorial brain disorder characterized by gradual memory impairment, cognitive disturbance, and severe dementia, and, ultimately, its progression leads to patient death. This research work presents the design, synthesis, and ch...

全面介紹

書目詳細資料

發表在:	Pharmaceuticals
Main Authors:	Manal M. Khowdiary, Shoaib Khan, Tayyiaba Iqbal, Wajid Rehman, Muhammad Bilal Khan, Mujaddad Ur Rehman, Zanib Fiaz, Hakimullah
格式:	Article
語言:	英语
出版:	MDPI AG 2025-03-01
主題:	Alzheimer’s disease triazole-thiazolidinone molecular docking pharmacophore modeling MD simulations
在線閱讀:	https://www.mdpi.com/1424-8247/18/3/415