Claudin-9 (CLDN9) promotes gastric cancer progression by enhancing the glycolysis pathway and facilitating PD-L1 lactylation to suppress CD8+ T cell anti-tumor immunity

Background: Gastric cancer (GC) is a common malignancy characterized by the absence of reliable prognostic indicators and effective therapeutic targets. Claudin-9 (CLDN9) has been demonstrated to be upregulated in various cancers. However, its prognostic value, biological function, and regulatory me...

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Bibliographic Details

Published in:	Cancer Pathogenesis and Therapy
Main Authors:	Xingbin Hu, Wenhao Ouyang, Haizhu Chen, Zhihong Liu, Zijia Lai, Herui Yao
Format:	Article
Language:	English
Published:	Elsevier 2025-05-01
Subjects:	Gastric cancer Lactylation Glycolysis Immune evasion CLDN9 PD-L1
Online Access:	http://www.sciencedirect.com/science/article/pii/S2949713224000855