Synergistic Dual Targeting of Thioredoxin and Glutathione Systems Irrespective of p53 in Glioblastoma Stem Cells

Glioblastoma (GBM) is an incurable primary brain cancer characterized by increased reactive oxygen species (ROS) production. The redox-sensitive tumor suppressor gene <i>TP53</i>, wild-type (wt) for 70% of patients, regulates redox homeostasis. Glioblastoma stem cells (GSCs) increase thi...

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Bibliographic Details
Published in:Antioxidants
Main Authors: Fatemeh Jamali, Katherine Lan, Paul Daniel, Kevin Petrecca, Siham Sabri, Bassam Abdulkarim
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Subjects:
Glioblastoma
Glioblastoma stem cells (GSCs)
auranofin
thioredoxin reductase
oxidative stress
glutathione (GSH)
Online Access:https://www.mdpi.com/2076-3921/13/10/1201

Internet

https://www.mdpi.com/2076-3921/13/10/1201

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