VHL mutation-mediated SALL4 overexpression promotes tumorigenesis and vascularization of clear cell renal cell carcinoma via Akt/GSK-3β signaling

Abstract Background Although ongoing development of therapeutic strategies contributes to the improvements in clinical management, clear cell renal cell carcinoma (ccRCC) deaths originate mainly from radiochemoresistant and metastatic disease. Transcription factor SALL4 has been implicated in tumori...

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發表在:	Journal of Experimental & Clinical Cancer Research
Main Authors:	Jinbo Sun, Qisheng Tang, Yongheng Gao, Wei Zhang, Zhining Zhao, Fan Yang, Xiangnan Hu, Dan Zhang, Yong Wang, Huizhong Zhang, Bin Song, Bo Zhang, He Wang
格式:	Article
語言:	英语
出版:	BMC 2020-06-01
主題:	Clear cell renal cell carcinoma SALL4 Tumorigenesis Angiogenesis VHL mutation
在線閱讀:	http://link.springer.com/article/10.1186/s13046-020-01609-8