Rlip Reduction Induces Oxidative Stress and Mitochondrial Dysfunction in Mutant Tau-Expressed Immortalized Hippocampal Neurons: Mechanistic Insights

RalBP1 (Rlip) is a stress-activated protein that is believed to play a large role in aging and neurodegenerative diseases such as Alzheimer’s disease (AD) and other tauopathies. The purpose of our study was to understand the role of Rlip in mutant Tau-expressed immortalized hippocampal HT22 cells. I...

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Bibliographic Details

Published in:	Cells
Main Authors:	P. Hemachandra Reddy, Sudhir Kshirsagar, Chhanda Bose, Jangampalli Adi Pradeepkiran, Ashly Hindle, Sharda P. Singh, Arubala P. Reddy, Javaria Baig
Format:	Article
Language:	English
Published:	MDPI AG 2023-06-01
Subjects:	mutant Tau Rlip deficiency mitochondrial function phosphorylated tau oxygen consumption rate mitophagy
Online Access:	https://www.mdpi.com/2073-4409/12/12/1646