Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress

Summary: Recent studies have implicated a crucial role of Hippo signaling in cell fate determination by biomechanical signals. Here we show that mechanical loading triggers the activation of a Hippo-PKCζ-NFκB pathway in chondrocytes, resulting in the expression of NFκB target genes associated with i...

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Bibliographic Details

Published in:	iScience
Main Authors:	Xiaomin Cai, Christopher Warburton, Olivia F. Perez, Ying Wang, Lucy Ho, Christina Finelli, Quinn T. Ehlen, Chenzhou Wu, Carlos D. Rodriguez, Lee Kaplan, Thomas M. Best, Chun-Yuh Huang, Zhipeng Meng
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Subjects:	mechanobiology biological sciences molecular biology biomechanics
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004224012057