An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M β-lactamase drug-resistance enzymes

β-lactamases are a source of antibiotic resistance. Here, the authors show that an active site loop in β-lactamase toggles between conformations that control antibiotic hydrolysis and inhibitor susceptibility, highlighting the role of active site conformations in enzyme activity and inhibition.

Bibliographic Details

Published in:	Nature Communications
Main Authors:	Shuo Lu, Liya Hu, Hanfeng Lin, Allison Judge, Paola Rivera, Murugesan Palaniappan, Banumathi Sankaran, Jin Wang, B. V. Venkataram Prasad, Timothy Palzkill
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-11-01
Online Access:	https://doi.org/10.1038/s41467-022-34564-3