The Anti-Aggregative Peptide KLVFF Mimics Aβ1-40 in the Modulation of Nicotinic Receptors: Implications for Peptide-Based Therapy

In recent years, the inhibition of beta-amyloid (Aβ) aggregation has emerged as a potential strategy for Alzheimer’s disease. KLVFF, a small peptide corresponding to the aminoacidic sequence 16-20 of Aβ, reduces Aβ fibrillation dose dependently. Therefore, the toxic and functional characterization o...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Hanna Trebesova, Guendalina Olivero, Mario Marchi, Massimo Grilli
Format:	Article
Language:	English
Published:	MDPI AG 2022-09-01
Subjects:	KLVFF β-amyloid synaptosomes Alzheimer’s disease nicotinic receptors muscarinic receptors
Online Access:	https://www.mdpi.com/2227-9059/10/9/2231