Oleanane triterpenoids with C-14 carboxyl group from Astilbe grandis inhibited LPS-induced macrophages activation by suppressing the NF-κB signaling pathway

BackgroundExcessive inflammation poses significant risks to human physical and mental health. Astilbe grandis, a traditional Miao medicine, is renowned for its anti-inflammatory properties. However, the specific anti-inflammatory effects and mechanisms of many compounds within this plant remain uncl...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Lan Yue, Jinfang Luo, Chenliang Zhao, Jinfeng Zhao, Jianghai Ye, Kang He, Juan Zou
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-08-01
Subjects:	Astilbe grandis oleanane triterpenoids 3α-acetoxyolean-12-en-27-oic acid 3β-acetoxyolean-12-en-27-oic acid anti-inflammatory RAW 264.7 cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1413876/full