Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma

Histone deacetylases (HDACs) are enzymes that play a key role in regulating gene expression by remodeling chromatin structure. An imbalance of histone acetylation caused by deregulated HDAC expression and activity is known to promote tumor progression in a number of tumor types, including neuroblast...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Monica Phimmachanh, Jeremy Z. R. Han, Yolande E. I. O’Donnell, Sharissa L. Latham, David R. Croucher
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-10-01
Subjects:	neuroblastoma histone deacetylases histone deacetylase inhibitor acetylation differentiation apoptosis
Online Access:	https://www.frontiersin.org/article/10.3389/fcell.2020.578770/full