Integrating In Vitro BE Checker with In Silico Physiologically Based Biopharmaceutics Modeling to Predict the Pharmacokinetic Profiles of Oral Drug Products

<b>Objective</b>: The objective of this study was to develop a Physiologically Based Biopharmaceutics Modeling (PBBM) framework that can predict PK profiles in humans based on data generated from the BE Checker. <b>Methods</b>: Metoprolol and dipyridamole were selected as mod...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Takuto Niino, Takato Masada, Toshihide Takagi, Makoto Kataoka, Hiroyuki Yoshida, Shinji Yamashita, Atsushi Kambayashi
Format:	Article
Language:	English
Published:	MDPI AG 2025-09-01
Subjects:	BE Checker physiologically based biopharmaceutics modeling in vivo performance modeling and simulation bioequivalence
Online Access:	https://www.mdpi.com/1999-4923/17/9/1222