Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by debilitating heterotopic ossification (HO). The retinoic acid receptor gamma agonist, palovarotene, and antibody-mediated activin A blockade have entered human clinical trials, but how these therapeutic modalitie...

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Bibliographic Details

Published in:	eLife
Main Authors:	John B Lees-Shepard, Sarah-Anne E Nicholas, Sean J Stoessel, Parvathi M Devarakonda, Michael J Schneider, Masakazu Yamamoto, David J Goldhamer
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2018-09-01
Subjects:	fibrodysplasia ossificans progressiva palovarotene fibro/adipogenic progenitor heterotopic ossification activin A ACVR1
Online Access:	https://elifesciences.org/articles/40814