n-3 polyunsaturated fatty acids delay intervertebral disc degeneration by inhibiting nuclear receptor coactivator 4-mediated iron overload

Summary: n-3 polyunsaturated fatty acids (PUFAs) are closely related to the progression of numerous chronic inflammatory diseases, but the role of n-3 PUFAs in the intervertebral disc degeneration (IVDD) remains unclear. In this study, male C57BL/6 wildtype mice (WT group, n = 30) and fat-1 transgen...

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Bibliographic Details

Published in:	iScience
Main Authors:	Xiang Ao, Tao Jiang, Yuan Li, Weiyi Lai, Zhengnan Lian, Liang Wang, Minjun Huang, Zhongmin Zhang
Format:	Article
Language:	English
Published:	Elsevier 2024-02-01
Subjects:	Pharmacology Natural sciences Biological sciences Physiology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004223027980