Polo-like kinase-dependent phosphorylation of the synaptonemal complex protein SYP-4 regulates double-strand break formation through a negative feedback loop.

The synaptonemal complex (SC) is an ultrastructurally conserved proteinaceous structure that holds homologous chromosomes together and is required for the stabilization of pairing interactions and the completion of crossover (CO) formation between homologs during meiosis I. Here, we identify a novel...

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Bibliographic Details

Published in:	eLife
Main Authors:	Saravanapriah Nadarajan, Talley J Lambert, Elisabeth Altendorfer, Jinmin Gao, Michael D Blower, Jennifer C Waters, Monica P Colaiácovo
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2017-03-01
Subjects:	Polo-like kinase double-strand breaks SYP-4 synaptonemal complex meiosis
Online Access:	https://elifesciences.org/articles/23437