Substrate Stiffness of Bone Microenvironment Controls Functions of Pre-Osteoblasts and Fibroblasts In Vitro

The formation of bone in a bone defect is accomplished by osteoblasts, while the over activation of fibroblasts promotes fibrosis. However, it is not clear how the extracellular matrix stiffness of the bone-regeneration microenvironment affects the function of osteoblasts and fibroblasts. This study...

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Bibliographic Details

Published in:	Biomimetics
Main Authors:	Shenghan Gao, Bo Chen, Min Gao, Yue Xu, Xueyi Yang, Chun Yang, Shaoxia Pan
Format:	Article
Language:	English
Published:	MDPI AG 2023-08-01
Subjects:	substrate stiffness pre-osteoblast fibroblast bone regeneration biomimetic microenvironment
Online Access:	https://www.mdpi.com/2313-7673/8/4/344