Stimulation phosphatidylinositol 3-kinase/protein kinase B signaling by Porphyromonas gingivalis lipopolysacch aride mediates interleukin-6 and interleukin-8 mRNA/protein expression in pulpal inflammation

Background/purpose: The signaling mechanisms for Porphyromonas gingivalis lipopolysaccharide (PgLPS)-induced inflammation in human dental pulp cells are not fully clarified. This in vitro study aimed to evaluate the involvement of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway i...

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Bibliographic Details

Published in:	Journal of the Formosan Medical Association
Main Authors:	Yi-Ling Tsai, Chen-Ying Wang, Fu-Hsiung Chuang, Yu-Hwa Pan, Yan-Ru Lin, Kunaal Dhingra, Pai-Shien Liao, Fong-Shung Huang, Mei-Chi Chang, Jiiang-Huei Jeng
Format:	Article
Language:	English
Published:	Elsevier 2023-01-01
Subjects:	Protein kinase B Porphyromonas gingivalis Human dental pulp cells Interleukin Inflammation
Online Access:	http://www.sciencedirect.com/science/article/pii/S0929664622003138