Fluorescent Tagged Vaccinia Virus Genome Allows Rapid and Efficient Measurement of Oncolytic Potential and Discovery of Oncolytic Modulators

As a live biologic agent, oncolytic vaccinia virus has the ability to target and selectively amplify at tumor sites. We have previously reported that deletion of thymidine kinase and ribonucleotide reductase genes in vaccinia virus can increase the safety and efficacy of the virus. Here, to allow di...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Franck Gallardo, Doris Schmitt, Renée Brandely, Catherine Brua, Nathalie Silvestre, Annie Findeli, Johann Foloppe, Sokunthea Top, Sandrine Kappler-Gratias, Charlotte Quentin-Froignant, Renaud Morin, Jean-Michel Lagarde, Kerstin Bystricky, Stéphane Bertagnoli, Philippe Erbs
Format:	Article
Language:	English
Published:	MDPI AG 2020-11-01
Subjects:	oncolytic vaccinia virus poxvirus modulators fluorescence labeling live cell imaging
Online Access:	https://www.mdpi.com/2227-9059/8/12/543