Mineralocorticoid receptor antagonists in heart failure: a systematic review and meta-analysis

BackgroundMineralocorticoid receptor over-activation drives maladaptive myocardial fibrosis, vascular inflammation and renal sodium retention across the entire spectrum of left ventricular ejection fraction (LVEF). While steroidal MRAs have convincingly reduced hospitalizations and mortality in pati...

Full description

Bibliographic Details

Published in:	Frontiers in Cardiovascular Medicine
Main Authors:	Yue Zhang, Yin-Chao Bao, Li-Xia Wang, Hong-Juan Zhao, Jing Sun, Lin Sun, Wei Duan, Ming Du, Lei-Jun Wang, Qin-Yan An, Wen-Ze Yang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	mineralocorticoid receptor antagonists heart failure and reduced ejection fraction HF and mildly reduced ejection fraction HF with preserved ejection fraction hyperkalemia
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2025.1667236/full