Influence of YES1 Kinase and Tyrosine Phosphorylation on the Activity of OCT1

Organic cation transporter 1 (OCT1) is a transporter that regulates the hepatic uptake and subsequent elimination of diverse cationic compounds. Although OCT1 has been involved in drug-drug interactions and causes pharmacokinetic variability of many prescription drugs, details of the molecular mecha...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Muhammad Erfan Uddin, Dominique A. Garrison, Kyeongmin Kim, Yan Jin, Eric D. Eisenmann, Kevin M. Huang, Alice A. Gibson, Zeping Hu, Alex Sparreboom, Shuiying Hu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Subjects:	organic cation transporter 1 YES1 kinase tyrosine kinase inhibitors drug-transporter interactions post-translational modification
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.644342/full