A Modular Biomimetic Preclinical Platform to Elucidate the Interaction Between Cancer Cells and the Bone Metastatic Niche

Breast cancer (BC) frequently metastasizes to bone, leading to poor patient prognosis. The infiltration of cancer cells in bone impairs its homeostasis, triggering a pathological interaction between tumors and resident cells. Preclinical models able to mimic the bone microenvironment are needed to a...

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Bibliographic Details

Published in:	Journal of Functional Biomaterials
Main Authors:	Claudia Cocchi, Massimiliano Dapporto, Ania Naila Guerrieri, Chiara Liverani, Marta Tavoni, Chiara Bellotti, Chiara Spadazzi, Anna Tampieri, Marco Gambarotti, Giacomo Miserocchi, Simone Sprio, Enrico Lucarelli, Michele Iafisco, Toni Ibrahim, Alessandro De Vita, Laura Mercatali
Format:	Article
Language:	English
Published:	MDPI AG 2025-06-01
Subjects:	bone metastasis breast cancer preclinical platform tricalcium phosphate cements osteoclasts osteoblasts
Online Access:	https://www.mdpi.com/2079-4983/16/6/220