Syndecan-4 promotes gastric cancer progression through activating TGF-β1 induced lipid reprogramming and contributes positive loop circuits

Abstract Background Syndecan-4 (SDC4) plays a pivotal role in tumorigenesis through cell signaling, adhesion and matrix interactions. Lipid reprogramming is a core strategy for malignant tumors to drive progression and invasion through reshaping immunity, stromal and vascular ecology in microenviron...

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Bibliographic Details
Published in:Discover Oncology
Main Authors: Guangjie Liu, Ru Jia, Heng Deng, Xiaoshan Wang
Format: Article
Language:English
Published: Springer 2025-06-01
Subjects:
SDC4
TGF-β1
Smad3
Cell progression
Lipid reprogramming
Online Access:https://doi.org/10.1007/s12672-025-02975-5

Internet

https://doi.org/10.1007/s12672-025-02975-5

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