Identification and Engineering of Transporters for Efficient Melatonin Production in Escherichia coli

Transporter discovery and engineering play an important role in cell factory development. Decreasing the intracellular concentration of the product reduces product inhibition and/or toxicity. Lowering intracellular concentrations is especially beneficial for achieving a robust strain at high titers....

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Bibliographic Details

Published in:	Frontiers in Microbiology
Main Authors:	Lei Yang, Sailesh Malla, Emre Özdemir, Se Hyeuk Kim, Rebecca Lennen, Hanne B. Christensen, Ulla Christensen, Lachlan J. Munro, Markus J. Herrgård, Douglas B. Kell, Bernhard Ø. Palsson
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Subjects:	membrane transporter E. coli inhibition production identification
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2022.880847/full