Enduring Effects of Conditional Brain Serotonin Knockdown, Followed by Recovery, on Adult Rat Neurogenesis and Behavior

Serotonin (5-hydroxytryptamine, 5-HT) is a crucial signal in the neurogenic niche of the hippocampus, where it is involved in antidepressant action. Here, we utilized a new transgenic rat model (TetO-shTPH2), where brain 5-HT levels can be acutely altered based on doxycycline (Dox)-inducible shRNA-e...

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Bibliographic Details

Published in:	Cells
Main Authors:	Maria Sidorova, Golo Kronenberg, Susann Matthes, Markus Petermann, Rainer Hellweg, Oksana Tuchina, Michael Bader, Natalia Alenina, Friederike Klempin
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Subjects:	serotonin <i>Tph2</i> depression neurogenesis stem cells BrdU
Online Access:	https://www.mdpi.com/2073-4409/10/11/3240