The stability of the primed pool of synaptic vesicles and the clamping of spontaneous neurotransmitter release rely on the integrity of the C-terminal half of the SNARE domain of syntaxin-1A

The SNARE proteins are central in membrane fusion and, at the synapse, neurotransmitter release. However, their involvement in the dual regulation of the synchronous release while maintaining a pool of readily releasable vesicles remains unclear. Using a chimeric approach, we performed a systematic...

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Bibliographic Details

Published in:	eLife
Main Authors:	Andrea Salazar Lázaro, Thorsten Trimbuch, Gülçin Vardar, Christian Rosenmund
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2024-03-01
Subjects:	neurotransmitter release exocytosis SNARE complex spontaneous release evoked release synapse
Online Access:	https://elifesciences.org/articles/90775